Drug Interactions

When Used As Directed, TYLENOL® Has Less Drug Interaction Risk Than Other Over-The-Counter Pain Relievers

When you take some pain relievers with over-the-counter or prescription medicines, they may interact with each other-changing the way one or both of them work in your body. This may cause side effects.

NSAID pain relievers, as well as a class of prescription medicines known as COX-2 inhibitors, may cause undesirable side effects. (Celebrex® is a COX-2 inhibitor.) NSAIDs are sometimes known to interact with certain prescription medicines.

TYLENOL® is not an NSAID or a COX-2 inhibitor. It's a pain reliever that works differently and, when used as directed, has less drug interaction risk than other over-the-counter pain relievers you may be taking. Do not use TYLENOL® with other acetaminophen-containing products. Always read and follow labeled directions.

TYLENOL® is the over-the-counter pain reliever doctors recommend most for patients who also take medicines for high blood pressure, asthma, ulcers, and even patients who take a prescription NSAID for arthritis.