NSAIDs

What is a non-steroidal anti-inflammatory drug (NSAID)?

Non-steroidal anti-inflammatory drugs (NSAIDs), which include naproxen sodium, aspirin, and ibuprofen, elevate the body's overall pain threshold so that you feel less pain. In addition, NSAIDs also work on a chemical level. They block the effects of certain enzymes, specifically COX 1 and COX 2 enzymes. These enzymes play a key role in producing chemicals called prostaglandins. There are different types of prostaglandins that have important roles in the body. Some prostaglandins have a direct role in pain and by temporarily blocking these prostaglandins, you relieve pain. Other prostaglandins play an important role in protecting the stomach and gastrointestinal (GI) lining. NSAIDs temporarily block that production of these prostaglandins and as a result, the stomach can become more vulnerable to GI side effects. Some prostaglandins also promote blood flow to impaired kidneys. By blocking the production of these prostaglandins, NSAIDs reduce blood flow to compromised kidneys, which can make them work more slowly. When kidneys are not working well especially in patients with existing kidney disease, fluid can build up in the body. This can have an effect on blood pressure.

Is TYLENOL^® a non-steroidal anti-inflammatory drug (NSAID)?

TYLENOL^® is not an NSAID. The active ingredient in TYLENOL^® is acetaminophen.