Aspirin Heart Therapy

TYLENOL® won’t interfere with your aspirin heart therapy the way ibuprofen can. That’s a benefit worth saving.

TYLENOL® & your daily low-dose aspirin heart therapy regimen

If you’ve talked to your doctor about taking aspirin for heart health, you’re not alone. The American Heart Association suggests some people at high risk of heart attack may benefit from a daily aspirin heart therapy regimen (if told by their healthcare provider) and that regularly taking low-dose aspirin may help heart attack survivors prevent another heart attack occurrence.

However, this may lead you to wonder what pain reliever is best to take with low-dose aspirin. Read on to discover how different active ingredients may affect your daily aspirin heart regimen that your doctor may recommend.

Can you take aspirin and TYLENOL® together?

Taking aspirin for heart health is a decision you should make with your doctor. They can help you to understand that acetaminophen, the active ingredient in TYLENOL®, can be an appropriate pain relief option for patients on aspirin heart therapy because it does not inhibit the heart-healthy benefits of your aspirin therapy and does not irritate the stomach the way that naproxen sodium or even ibuprofen can. For people on aspirin heart therapy, TYLENOL® is the brand of pain reliever recommended most often by doctors, more than all other name brands combined.

NOTE: Aspirin is not appropriate for everyone so please be sure to talk to your doctor before you begin an aspirin regimen.

How some pain relievers can interact with your aspirin heart therapy

Aspirin & Other NSAIDS

Taking aspirin or other NSAIDs to treat pain when you’re already on aspirin heart therapy can increase your risk of side effects such as stomach bleeding. Ask your doctor for pain relief recommendations if you are on aspirin heart therapy.


When you take ibuprofen, the active ingredient in Advil® & MOTRIN®, it can compete with the positive benefits of your aspirin heart therapy. Specifically, it blocks certain receptors that are needed for aspirin’s cardiovascular effects.

Things to consider if you are on aspirin heart therapy*

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If you have experienced a heart attack, cardiac rehabilitation through exercise may help restore your heart health

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Eating a heart-healthy diet consisting of fish, fruits, vegetables, beans and whole grains can help lower the risk of heart disease

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Consider TYLENOL® for pain relief because it won’t interfere with the benefits of aspirin heart therapy

*Talk to your healthcare professional if you have any questions or concerns.

Learn more about safe use of TYLENOL® here or explore our range of products to help reduce fever, relieve pain and other symptoms.