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Aspirin Heart Therapy

TYLENOL® won’t interfere with your aspirin heart therapy. That’s a benefit worth saving.

TYLENOL® & Your Aspirin Regimen

If you’ve talked to your doctor about taking aspirin for heart health, you’re not alone. The American Heart Association recommends people at high risk of heart attack should take a daily low-dose of aspirin (if told by their healthcare provider) and that heart attack survivors regularly take low-dose aspirin. Taking aspirin for heart health is a decision you should make with your doctor. They can help you to understand that acetaminophen, the active ingredient in TYLENOL®, gives you strong pain relief and won’t interfere with your aspirin heart therapy the way ibuprofen can.

NOTE: Aspirin is not appropriate for everyone so please be sure to talk to your doctor before you begin an aspirin regimen.

Things to consider if you are on aspirin heart therapy*

*Talk to your healthcare professional if you have any questions or concerns.

How some pain relievers can interact with your aspirin heart therapy


Taking aspirin or other NSAIDs to treat pain when you’re already on aspirin heart therapy can increase your risk of side effects such as stomach bleeding. Ask your doctor for pain relief recommendations if you are on aspirin heart therapy.


When you take ibuprofen, the active ingredient in Advil® & MOTRIN®, it can compete with the positive benefits of your aspirin heart therapy. Specifically, it blocks certain receptors that are needed for aspirin’s cardiovascular effects. 

Did you know?

Acetaminophen, the active ingredient in TYLENOL®, can be an appropriate pain relief option for patients on aspirin heart therapy because it does not inhibit the heart-healthy benefits of your aspirin therapy and does not irritate the stomach the way that naproxen sodium or even ibuprofen can. For people on aspirin heart therapy, TYLENOL® is the brand of pain reliever recommended most often by doctors, more than all other brands combined.

Pain relief you can count on.

Use only as directed.

Knowing how to read the label is important.
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