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Sleeplessness & High Blood Pressure

If you are experiencing occasional sleeplessness and have high blood pressure or are taking medication to help manage high blood pressure, you may be wondering which over-the-counter (OTC) nighttime sleep aid options may be right for you. TYLENOL® PM and SIMPLY SLEEP® both contain the active ingredient diphenhydramine. Read more about diphenhydramine and high blood pressure below. Click here to buy a TYLENOL® PM product.

Can I take TYLENOL® products with diphenhydramine sleep aid if I have high blood pressure?

If you have high blood pressure and are experiencing pain and sleeplessness TYLENOL® PM may be an appropriate pain reliever/nighttime sleep aid option for you. SIMPLY SLEEP® may also be an appropriate nighttime sleep aid for those with high blood pressure who experience occasional sleeplessness without pain.

You’re not alone

Nearly half of all US adults suffer from high blood pressure1 (hypertension) and in one study 80% of patients with high blood pressure were unaware that NSAIDs can interfere with certain antihypertensives2. The CDC also found that >1 in 3 adults don’t get enough sleep on a regular basis 3.

Know the facts

Chronic stress leads to lack of sleep and other manifestations of pain. Lack of sleep is linked to poor health and has been associated with the following health risks:

Elevated blood pressure
Increased risk of cardiovascular disease
Increased risk of stroke
Type 2 diabetes
Decreased immune function
Weight gain & obesity
Increased inflammation

Always read and follow your pain medication label

Nighttime sleep aids containing NSAIDs like ibuprofen (e.g. Advil® PM, MOTRIN® PM) and naproxen sodium (e.g. Aleve® PM) can produce several effects on your body that may further worsen high blood pressure. NSAIDs can:

Increase resistance of blood vessels (constricts blood flow), which can raise blood pressure.

Reduce the effectiveness of previously prescribed high blood pressure treatments

If you have questions on how pain relievers may affect blood pressure and if
TYLENOL® PM is an appropriate pain reliever for you, talk to your doctor.


TYLENOL® PM may be an appropriate OTC pain reliever/nighttime sleep aid with acetaminophen and diphenhydramine for you.


Simply Sleep® may be an appropriate OTC sleep aid with Diphenhydramine HCI if you’re experiencing sleeplessness without pain.

REMEMBER: Always talk to your doctor if you have a health condition or are taking prescription medicines before taking any pain reliever. If your pain hasn't subsided or gets worse after 10 days of use, you should stop taking your pain reliever and consult a physician. Is TYLENOL® PM right for you?

woman sleeping and sleep aids

Get the rest you need with helpful sleep aids.

Learn the basics about getting quality sleep.

1. American College of Cardiology. New ACC/AHA high blood pressure guidelines lower definition of hypertension. Accessed January 12, 2018
2. Data on file. Johnson & Johnson Consumer Inc., McNeil Consumer Healthcare Division. 2017.
3. Centers for Disease Control and Prevention. 1 in 3 adults don’t get enough sleep.
4. Division of Sleep Medicine at Harvard Medical School.

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