Potential Benefits of Topical Analgesic Cream for Pain Relief

Stop pain where it hurts with the targeted pain relief of TYLENOL® PRECISE.

What Are Topical Analgesics and How Do They Work?

A topical analgesic is a medicine that’s applied to the skin to relieve pain in your muscles and joints alike. Unlike other pain relievers like acetaminophen, they should not be taken by mouth (orally).

Some topical analgesics relieve pain by working to reduce inflammation, while others change how you process pain.1 Common ingredients in topical analgesics include:2

  • Lidocaine
  • Capsaicin
  • Menthol
  • Camphor
  • Diclofenac
  • Methyl salicylate

You can find these ingredients in different dosage forms such as creams, ointments, gels, or patches.1

Potential Benefits of Topical Analgesics for Pain Relief

There are several advantages to applying your pain relief medication directly to the affected area.

1. Targeted Pain Relief

Get rapid pain relief where you need it by applying it directly where it hurts. When a topical analgesic is applied to the affected area, it provides targeted pain relief.

2. Easy-To-Use

Simply apply the cream for pain relief where it’s needed and wait. With a topical pain reliever, you don’t need any water to swallow pills. Topical pain relievers are convenient to have on hand whenever pain hits.

3. Favorable Safety Profile When Used As Directed

While topical analgesics can cause side effects, they often can be milder than the potential side effects of many oral pain relievers. The most common side effect for most topical analgesics is irritation in the place it was applied.1 Always read and follow the product label and talk to your doctor if you have any questions about the use of a topical pain reliever.

4. Relief Across Multiple Pain Types

Topical analgesics can treat several types of pain.1 Topical analgesics can help relieve:2


TYLENOL® PRECISE causes topical lidocaine cream to provide fast pain relief where you need it. The unique formula in TYLENOL® PRECISE adds even more to the benefits of topical analgesics, such as:

TYLENOL® PRECISE Rollerball Applicator

The rollerball applicator helps you easily target your pain without the mess. It can even help you get those hard-to-reach spots.

Fast Pain Relief

When you apply topical lidocaine to the affected area, it can give you fast relief from muscle pain.

Lidocaine Active Ingredient

Topical lidocaine helps numb your pain away by blocking your nerve cells from sending pain signals.6

Advanced Hydration Technology

The advanced hydration technology in TYLENOL® PRECISE cream can help you avoid skin dryness.


The fragrance-free formula avoids using chemicals that does not have a smell.7 It also makes sure the people around you don’t know that you’ve applied it.

Cooling Relief

TYLENOL® PRECISE with menthol provides cooling for dual action pain relief. Menthol adds a cooling effect that can help desensitize the nerves in your skin from feeling pain.8

Learn more about TYLENOL® PRECISE and where you can purchase it by clicking here.

Related content


1. Jorge LL, Feres CC, Teles VE. Topical preparations for pain relief: efficacy and patient adherence. Journal of Pain Research. 2010; 4, 11–24.

2. External analgesic drug products for over-the-counter human use: tentative final monograph. FDA. Fed Regist. 1983;48(27):5852. Accessed May 29, 2023.

3. Pain Relievers. Cleveland Clinic. Updated April 13, 2021. Accessed May 30, 2023. https://my.clevelandclinic.org/health/treatments/12058-pain-relievers

4. Voute M, Morel V, Pickering G. (2021). Topical Lidocaine for Chronic Pain Treatment. Drug Design, Development and Therapy. 2021; 15, 4091–4103.

5. Bushra R, Aslam N. An overview of clinical pharmacology of Ibuprofen. Oman Medical Journal. 2010. 25(3), 155–1661.

6. Lidocaine (Topical Application Route). Mayo Clinic. Updated May 1, 2023. Accessed May 30, 2023.

7. Safer Choice Fragrance-Free. Environmental Protection Agency. Published October 2016, Accessed May 31, 2023. https://www.epa.gov/sites/default/files/2016-10/documents/saferchoice-factsheet-fragrancefree_0.pdf

8. Pergolizzi JV, Taylor R, LeQuang A, et al. The role and mechanism of action of menthol in topical analgesic products. Journal of Clinical Pharmacy and Therapeutics. 2018; 43(3),