Common Questions About TYLENOL^® with Naproxen: Myths and Facts Explained

When researching pain relief options, it's common to come across conflicting information about ingredients, pain relievers, and how different products work. Understanding what's true and what's not can help you make informed decisions and choose a pain relief option that fits your needs.

MYTH

Some people may assume TYLENOL® with Naproxen is simply another version of traditional, single-ingredient TYLENOL® (acetaminophen).

The Fact

TYLENOL® with Naproxen contains both acetaminophen and naproxen sodium in a single fixed-dose product, while traditional, single-ingredient TYLENOL® products containing acetaminophen have one active pain-relieving ingredient.

Because it combines two active ingredients, TYLENOL® with Naproxen offers a different over-the-counter pain relief option than products containing acetaminophen alone. It starts to work in 30 minutes and delivers effective pain relief for 12 hours.

MYTH

Some people may think that acetaminophen and naproxen sodium work the same way.

The Fact

Acetaminophen and naproxen sodium are different ingredients that work differently to help relieve pain.^[1,2] TYLENOL® with Naproxen combines these two complementary pain relievers in one fixed-dose product.

MYTH

Some people may assume strong, or longer-lasting pain relief products contain opioid ingredients.

The Fact

TYLENOL® with Naproxen does not contain opioids. It is an opioid-free pain relief option. TYLENOL® with Naproxen provides an opioid-free option that is available without a prescription.

FACT

Naproxen sodium belongs to a class of medicines known as nonsteroidal anti-inflammatory drugs (NSAIDs).^[2] This is one of the key differences between naproxen sodium and acetaminophen, which is not classified as an NSAID.^[1]

MYTH

Some people may think that acetaminophen is a NSAID.

The Fact

Acetaminophen is a pain reliever, but it does not belong to the NSAID category of medications.^[1] Understanding the difference between active ingredients can help you better understand the range of available pain relief options.

FACT

TYLENOL® with Naproxen combines the fast-acting relief of acetaminophen with the long-lasting power of naproxen sodium, starting to work in under 30 minutes and delivering effective pain relief for 12 hours.

Different pain relievers may offer different durations of relief depending on their active ingredients and directions for use.

MYTH

Some people may think that TYLENOL® with Naproxen limited to a single type of pain or pain occasion.

The Fact

TYLENOL® with Naproxen is indicated for the temporary relief of minor aches and pains, including:

• Headache

• Backache

• Muscle aches

• Toothache

• Minor arthritis pain

• Menstrual cramps

Always read and follow the Drug Facts label for complete indications, directions, and warnings.

TYLENOL® with Naproxen is the only FDA-approved over-the-counter (OTC) pill to combine acetaminophen and naproxen sodium. It delivers faster, stronger relief that lasts 12 hours in one potent, opioid-free dose.*

TYLENOL® with Naproxen combines the fast-acting relief of acetaminophen with the long-lasting power of a non steroidal anti-inflammatory drug, naproxen sodium, starting to work in under 30 minutes and delivering effective pain relief for 12 hours.

The potent, opioid-free pain reliever combines two complementary pain relievers in one dose: 650 mg of acetaminophen with 220 mg of naproxen sodium and is clinically proven to be more effective than Aleve 220 mg.

Millions of Americans experience persistent pain, and until now, OTC options have been limited on both duration and strength, leaving 75% of sufferers dissatisfied with their relief. [3] It’s more important than ever to expand safe, effective non-opioid options for both consumers and healthcare providers. TYLENOL® with Naproxen provides a stronger* solution that lasts 12 hours and is available without a prescription or opioid risk.

TYLENOL® with Naproxen expands the range of available OTC pain relief options by combining acetaminophen and naproxen sodium in a single fixed-dose product.

TYLENOL® with Naproxen contains the following active ingredients in each dose:

• 650 mg acetaminophen

• 220 mg naproxen sodium

Acetaminophen is a pain reliever. Naproxen sodium belongs to a class of medicines known as nonsteroidal anti-inflammatory drugs (NSAIDs).

Together, these complementary ingredients create a fixed-dose combination designed to provide fast-acting and long-lasting pain relief in a single OTC dose.

Fact: Not All Over-the-Counter Pain Relievers Are the Same

Different OTC pain relievers contain different active ingredients and work differently. Knowing what's in your pain reliever can help you choose a product that fits your needs and avoid accidentally taking medicines that contain the same active ingredient.

Fact: Every Pain Reliever Has Important Safety Information

All medicines carry benefits and risks. NSAIDs such as naproxen sodium may cause severe stomach bleeding and can increase the risk of heart attack, heart failure, and stroke. Acetaminophen may cause serious liver damage if you take with other drugs containing acetaminophen, if you take more than 4,000 mg of acetaminophen in 24 hours or if you have 3 or more alcoholic drinks everyday while using the product. Always read and follow all warnings and directions on the Drug Facts label.

Fact: Healthcare Providers Can Help Answer Questions About Pain Relief

Everyone experiences pain differently. If you're unsure which pain relief option may be right for you, talk with a healthcare provider or pharmacist. They can help answer questions about ingredients, dosing, and pain relief options.