The American Heart Association identifies acetaminophen (TYLENOL®) as a pain relief option to try first* for patients with, or at high risk for, cardiovascular disease, as it is not known to increase risks of heart attack, heart failure, or stroke.

NSAIDs, like ibuprofen (e.g. Advil®, MOTRIN®) and naproxen sodium (e.g. Aleve®), may increase the risk of heart attack, heart failure, and stroke. The risk is higher if you use more than directed or for longer than directed. Stop use and ask your doctor if you have symptoms of heart problems or stroke, while taking OTC ibuprofen or naproxen sodium.

*When symptoms are not controlled by non-pharmacological approaches

A variety of factors contribute to your risk of cardiovascular disease.

A variety of factors contribute to your risk of cardiovascular disease. Your doctor can use these factors to help identify your personal level of risk. Some major risk factors include:

Health Conditions

High Blood Pressure

Aspirin Heart Therapy

Acetaminophen (TYLENOL^®)

TYLENOL^® does not interfere with certain blood pressure control medications the way NSAIDs sometimes can.

For people on aspirin heart therapy, TYLENOL® is the brand of pain reliever recommended most often by doctors, more than all other brands combined

It does not interfere with aspirin’s ability to protect against heart attack or stroke, like ibuprofen (e.g. Advil®, MOTRIN®) or naproxen sodium (e.g. Aleve®) can.

Health Condition & Acetaminophen(TYLENOL^®)

High Blood Pressure

TYLENOL^® does not interfere with certain blood pressure control medications the way NSAIDs sometimes can.

Aspirin Heart Therapy

For people on aspirin heart therapy, TYLENOL® is the brand of pain reliever recommended most often by doctors, more than all other brands combined. It does not interfere with aspirin’s ability to protect against heart attack or stroke, like ibuprofen (e.g. Advil®, MOTRIN®) or naproxen sodium (e.g. Aleve®) can.